The spleen: function and pathology; splenectomy

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  2. Rotbain et al. Splenomegaly – Diagnostic validity, work-up, and underlying causes. PLOS One 2017;12:e0186674
  3. Sjoberg et al. Splenomegaly: A Combined Clinical and Radiologic Approach to the Differential Diagnosis. Gastroenterol Clin North Am 2018;47:643
  4. Rubin and Schaffner. Care of the asplenic patient. NEJM 2014;371:349
  5. O’Neal et al. Critical illness in patients with asplenia. Chest 2016;150:1394
  6. Ianitto and Tripodo. How I diagnose and treat splenic lymphomas. Blood 2011;117:2585(DDx of massive splenomegaly)
  7. British Committee for Standards in Haematology Clinical Haematology Task Force. Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen.  BMJ 1996;312:430
  8. Halfdanarson et al. Hematologic manifestations of celiac disease. Blood 2007;109:412 (Celiac disease as a cause of hyposplenism)
  9. Schilling et al. Delayed adverse vascular events after splenectomy in hereditary spherocytosis. J Thromb Haemost 2008; 6:1289(7-fold increase in risk of arterial events, 3-fold increase in risk for venous thrombosis)
  10. Crary and Buchanan. Vascular complications after splenectomy for hematologic disorders. Blood 2009;114:2861
  11. Thomsen et al. Risk for Hospital Contact With Infection in Patients With Splenectomy. A Population-Based Cohort Study. Ann Intern Med 2009; 151:546(4.6-fold increased risk for infection in first year after splenectomy, 2.5-fold increased risk thereafter; risk highest in those splenectomized for hematologic disorders)
  12. Adriani et al. Bacterial Meningitis in Adults After Splenectomy and Hyposplenic States. Mayo Clin Proc 2013;88:571 (Increased risk for pneumococcal meningitis; vaccination partially protective)
  13. Boyle et al. Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia. Blood 2013;121:4782
  14. Bolze et al. Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia. Science 2013;340:976
  15. Kang et al. An extracorporeal blood cleansing-device for sepsis therapy. Nat Med 2014;20:1211(An “artificial spleen”)