University of Wisconsin Hematology

Hematopoiesis: regulation and disorders thereof

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  10. Crispino and Horwitz. GATA factor mutations in hematologic disease. Blood 2017;129:2103
  11. Möröy et al. From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation. Blood 2015;126:2561
  12. Khan et al. Fetal liver hematopoietic stem cell niches associate with portal vessels. Science 2016;351:176
  13. Notta et al. Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment. Science 2011;333:218
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  17. Fares et al. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science 2014;345:1509 (Small molecules that stimulate expansion of human hematopoietic stem cells)
  18. Chen et al. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature 2016;530:223
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  23. Caulier and Sankaran. Molecular and cellular mechanisms that regulate human erythropoiesis. Blood 2022;139:2450
  24. Cazzola M. Ineffective erythropoiesis and its treatment. Blood 2022;139:2480
  25. Ito et al. Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance. Science 2016;354:1156(With editorial)
  26. Heidt et al. Chronic variable stress activates hematopoietic stem cells. Nat Med 2014;20:754(With editorial)
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  29. Asquith et al. The bone marrow is the primary site of thrombopoiesis. Blood 2024;143:272 (Minor contribution from lung megakaryocytes)
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  31. Bruns et al. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med 2014;20:1315(with editorial)
  32. Zhao et al. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med 2014;20:1321(with editorial)
  33. Nishimura et al. IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol 2015;209:453(Alternative mechanism for rapid platelet release in inflammatory states)
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  35. Lisman et al. The circulating platelet count is not dictated by the liver, but may be determined in part by the bone marrow: analyses from human liver and stem cell transplantations. J Thromb Haemost 2012;10:1624
  36. Schwertz et al. Anucleate platelets generate progeny. Blood 2010;115:3801(Thrombopoiesis may continue after platelets enter the bloodstream)
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  38. Stone et al. The bone marrow niche from the inside out: how megakaryocytes are shaped by and shape hematopoiesis. Blood 2022;139:483
  39. Furniss et al. Platelet generation in vivo and in vitro. Blood 2024;144:2283
  40. Overbeeke et al. The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination. Blood 2022;139:2285
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