Anemia of inflammation and other anemias

  1. Fishbane and Coyne. How I treat renal anemia. Blood 2020;136:783
  2. Anand and Gupta. How I treat anemia in heart failure. Blood 2020;136:790
  3. Gilreath and Rodgers. How I treat cancer-associated anemia. Blood 2020;136:801
  4. Shander et al. How I treat anemia in the perisurgical setting. Blood 2020;136:814
  5. Weiss et al. Anemia of Inflammation. Blood 2019;133:40
  6. Marques et al. The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation. Blood 2022;140:2011
  7. Vallurupalli et al. Effects of Interleukin-1β Inhibition on Incident Anemia. Exploratory Analyses From a Randomized Trial. Ann Intern Med 2020;172:523 (Canakinumab reduced incidence of anemia in parallel with its anti-inflammatory effect)
  8. Sramek et al.  Anemia with impaired erythropoietin response in diabetic patients. Arch Intern Med. 2005;165:466
  9. Ble et al. Renal Function, Erythropoietin, and Anemia of Older Persons. The InCHIANTI Study. Arch Intern Med 2005;165:2222(CrCl less than 30 associated with low EPO levels and anemia in individuals >65)
  10. Roy et al. Association of Testosterone Levels With Anemia in Older Men. A Controlled Clinical Trial. JAMA Intern Med 2017;177:480(Testosterone gel treatment increased Hb by 1 gram or more in over 50%)
  11. Tomosugi et al. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood 2006;108:1381    (Accumulation of hepcidin in the blood in renal failure may limit iron availability)
  12. Song et al. Down-regulation of hepcidin resulting from long-term treatment with an anti–IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood 2010;116:3627(Evidence that IL-6 induces hepcidin production in this condition)
  13. van Eijk et al. Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood 2014;124:2643(Hepcidin inhibitor raised serum iron levels vs placebo)
  14. Semba et al. The Impact of Anemia on Energy and Physical Functioning in Individuals With AIDS. Arch Intern Med 2005;165:2229
  15. Perlstein et al. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011;117:2800
  16. Papadaki et al. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-antibody therapy. Blood 2002;100:474
  17. Dulmovits et al. HMGB1-mediated restriction of EPO signaling contributes to anemia of inflammation. Blood 2022;139:3181 (Mechanism of EPO-resistance)
  18. van der Meer et al. Levels of Hematopoiesis Inhibitor N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Partially Explain the Occurrence of Anemia in Heart Failure. Circulation 2005;112:1743(An inhibitor of hematopoiesis normally degraded by ACE accumulates in heart failure and is associated with anemia)
  19. Vanasse et al. A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Blood 2011;118:5401
  20. Lesheim-Rubinow et al. Association of angiotensin-converting enzyme inhibitor therapy initiation with a reduction in hemoglobin levels in patients without renal failure. Mayo Clin Proc 2012;87:1189
  21. Achebe and Gafter-Gvilli. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood 2017;129:940
  22. Aroda et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab 2016;101:1754(Long term metformin use associated with higher incidence of anemia, regardless of B12 status)