Modified Rai System
Rai et al, Blood 1975;46:219
| Level of risk | Stage | Description |
| Low | 0 | Lymphocytosis only (blood and marrow) |
| I | Lymphocytosis plus enlarged lymph nodes | |
| Intermediate | II | Lymphocytosis plus enlarged spleen and/or liver, ± lymphocytosis |
| III | Lymphocytosis plus anemia (Hgb <11 g), ± enlarged nodes, spleen or liver |
|
| High | IV | Lymphocytosis plus thrombocytopenia (plts < 100K), ± anemia, enlarged nodes, spleen or liver |
Binet System
Binet et al, Cancer 1981;48:198
| Stage | Description |
| A | Lymphocytosis with two or less node-bearing areas enlarged |
| B | Lymphocytosis with more than two node-bearing areas enlarged |
| C | Anemia (hemoglobin < 10 g) or thrombocytopenia (plts < 100K) |